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[Studies on senility retarding effect of qiangshengye liquid]
1Department of Pharmacology, Capital University of Medical Sciences, Beijing 100054, China.
Objective:
To observe the effect of Qiangshengye liquid on senility retarding in rats.
Methods:
The liquid was orally administrated to rats at doses of 3.3 g.kg-1 and 6.6 g.kg-1, and after Twenty-one days the activity of superoxide dismutase (SOD) in red blood cells and lipid peroxide(LPO) in plasma and in liver were examined respectively by spectrophotometry. Fluorescence polarization was used to evaluate the fluidity of erythrocyte membrane. In addition the anti-fatigue effect of the liquid in mice was detected.
Results:
The liquid can significantly increase the activity of SOD(P < 0.05) in red blood cells and decrease the contents of LPO in plasma (P < 0.05) and in liver(P < 0.01). The fluidity of erythrocyte membrane was also improved (P < 0.05).
Conclusion:
Qiangshengye liquid can antagonize lipid peroxidation and therefore may be used for anti-fatigue and senility retarding purposes.