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Related Experiment Videos

Epithelial-induced intrapulpal denticles in B6C3F1 mice.

Philip H Long1, Ronald A Herbert

  • 1Pathology Associates, A Charles River Company, West Chester, Ohio 45069, USA. plong@criver.com

Toxicologic Pathology
|January 7, 2003
PubMed
Summary

Intrapulpal denticles, calcified structures in mouse incisors, were identified. These denticles can disrupt normal tooth development, leading to dental dysplasia and fractures.

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Area of Science:

  • Dental Histology
  • Mouse Models
  • Toxicology

Background:

  • Intrapulpal denticles are calcified structures found within the pulp chamber of teeth.
  • Their formation and impact on tooth development are not fully understood.

Purpose of the Study:

  • To investigate the occurrence and histological characteristics of intrapulpal denticles in B6C3F1 mice.
  • To determine the potential effects of intrapulpal denticles on tooth development and integrity.

Main Methods:

  • Histological examination of maxillary incisors from control and treated B6C3F1 mice.
  • Observation of denticle origin, structure, and progression during incisor growth.

Main Results:

  • Multiple intrapulpal denticles were observed in maxillary incisors of both control and treated mice.
  • Denticles originated from epithelial sheath projections and exhibited tubular dentin.
  • Advanced denticles caused defects in dentinogenesis, altered tooth shape, microfractures, and incorporation into dentin.

Conclusions:

  • Intrapulpal denticle formation is a previously unidentified alteration in mouse incisors.
  • These denticles interfere with normal tooth development, potentially causing dental dysplasia and increasing susceptibility to malformation and fracture.

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