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Updated: Aug 15, 2026

Nonhuman Primate Lung Decellularization and Recellularization Using a Specialized Large-organ Bioreactor
Published on: December 15, 2013
Transport of oxygen and carbon dioxide by hemoglobin-saline solution in the red cell-free primate
Abstract:
This study was undertaken to investigate the respiratory properties of hemoglobin-saline solution. Eighteen baboons were exchange transfused with either 6 per cent dextran or 6 per cent hemoglobin-saline solution. All of the hemoglobin-saline solution treated baboons survived three hours at a zero hematocrit reading. All the dextran treated animals died when the hematocrit level fell below 6 per cent. Oxygen consumption and carbon dioxide production remained unchanged from base line during the zero hematocrit interval. It is concluded that the respiratory capability of hemoglobin-saline solution is sufficient to maintain life in the absence of erythrocytes.
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