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Updated: Sep 27, 2026

Induction of Intestinal Graft-versus-host Disease and Its Mini-endoscopic Assessment in Live Mice
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Published on: February 11, 2019

[Role of interleukin-18 in pathogenesis of acute graft-versus-host disease]

Xiao-Ping Ju1, Jian-Min Wang, Jun Hou

  • 1Department of Hematology, The Affiliated Changhai Hospital, The Second Military Medical University, Shanghai 200433, China.

Zhongguo Shi Yan Xue Ye Xue Za Zhi
|January 7, 2003
PubMed

To investigate the relationship between interleukin-18 (IL-18) and human acute graft-versus-host disease (aGVHD), 26 patients undergoing allogeneic peripheral blood stem cell transplantation (allo-PBSCT) were included in this study. IL-18 secreted by peripheral blood mononuclear cells (MNCs) was measured by enzyme-linked immunosorbent assay (ELISA) before transplantation and during aGVHD. The results showed that grade I GVHD and grades III-IV GVHD developed in 10 and 5 cases, respectively. The levels in the supernatants of MNCs from patients with aGVHD were significantly higher than those in the cases without aGVHD. The levels of IL-18 were correlated with the severity of aGVHD. It is concluded that IL-18 plays an important role in the development of aGVHD.

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