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Related Experiment Videos

Cheilognathoschisis in Texel sheep.

P Hoekstra, P Wensvoort

    Tijdschrift Voor Diergeneeskunde
    |January 15, 1976
    PubMed
    Summary

    Abnormal Texel lambs exhibited inherited defects, including cleft lip and palate (cheilognathoschis), light birth weight, and heart defects. These malformations are transmitted by a recessive autosomal gene.

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    Area of Science:

    • Veterinary Genetics
    • Animal Breeding
    • Teratology

    Background:

    • The birth of abnormal Texel lambs sired by a single ram prompted an investigation into potential inherited defects.
    • Previous literature did not describe the specific malformations observed in these lambs.

    Purpose of the Study:

    • To determine if the observed malformations in Texel lambs are inherited defects.
    • To elucidate the mode of hereditary transmission for these defects.

    Main Methods:

    • Experimental matings were conducted using the ram that sired abnormal offspring.
    • Phenotypic analysis of six affected lambs was performed.
    • Literature review on ovine genetic disorders and teratogens.

    Main Results:

    • The study identified a previously undescribed inherited defect in Texel lambs.
    • Key features included cheilognathoschis (cleft lip and palate), often with low birth weight, brachycephaly (short head), and cardiac septal defects.
    • Significant placental changes were noted in one affected lamb.

    Conclusions:

    • The observed malformations represent a distinct inherited defect in Texel sheep.
    • Evidence suggests transmission via a recessive autosomal gene, excluding more complex inheritance patterns.

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