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Updated: Jul 16, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
[New substituted 4-thioxothiazolidin-2-one derivatives: synthesis and structural study]
J Chantegrel1, J C Albuquerque, V L Guarda
1Laboratoire de Chimie-Pharmacie, CNRS UPR 5077, Université Joseph Fourier, Grenoble I, F 38706 La Tronche Cedex, France.
Researchers synthesized fifteen novel thiazolidin-2-one derivatives. These compounds, featuring benzyl and phenacyl groups, will undergo testing for bacteriostatic activity against bacteria.
Area of Science:
- Organic Chemistry
- Medicinal Chemistry
Context:
- Thiazolidin-2-one derivatives are a class of heterocyclic compounds with diverse biological activities.
- The synthesis of novel derivatives is crucial for exploring new therapeutic agents.
Purpose:
- To synthesize and characterize novel 3-benzyl- and 3-phenacyl-4-thioxo-5-benzylidenethiazolidin-2-one derivatives.
- To investigate the physico-chemical properties of the newly synthesized compounds.
Summary:
- Fifteen new thiazolidin-2-one derivatives were synthesized through multi-step reactions including thionation, N-alkylation, and aldol condensation with aromatic aldehydes.
- The synthesized compounds possess benzyl and phenacyl substituents at the 3-position and benzylidene groups at the 5-position of the thiazolidin-2-one core.
- Physico-chemical properties of these novel heterocyclic compounds were analyzed.
Impact:
- The study expands the library of thiazolidin-2-one derivatives for potential pharmaceutical applications.
- These compounds are slated for evaluation of their bacteriostatic potential, contributing to the search for new antimicrobial agents.
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