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Updated: Sep 27, 2026
Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death
Published on: August 15, 2022
Combined off-pump coronary revascularization and lung resection
Cengiz Köksal1, Sabit Sarikaya, Mustafa Zengin
1Cardiovascular Surgery Clinic, Sureyyapasa SSK Thoracic and Cardiovascular Disease Hospital, Maltepe-Istanbul, Turkey. cengizkoksal@hotmail.com
Insights
Off-pump coronary artery bypass grafting (CABG) combined with lung resection offers a safer approach for patients with severe coronary artery disease and lung malignancies, avoiding cardiopulmonary bypass complications.
Area of Science:
- Cardiovascular Surgery
- Thoracic Oncology
- Anesthesiology
Background:
- Concomitant severe coronary artery disease and lung malignancies are rare but present significant surgical challenges.
- Conventional coronary artery bypass grafting (CABG) using cardiopulmonary bypass (CPB) with lung resection poses risks including increased blood loss and pulmonary complications.
- CPB's immunosuppressive effects may negatively impact tumor growth and dissemination.
Observation:
- This study reports on two patients diagnosed with both severe coronary artery disease and lung malignancies.
- Both patients underwent off-pump CABG and lung resection during the same surgical session.
Findings:
- Off-pump CABG, by avoiding CPB, mitigates the complications associated with extracorporeal circulation and heparinization.
- This approach potentially reduces perioperative and postoperative issues, including blood loss, pulmonary complications, and hospital stay.
Implications:
- Off-pump CABG in conjunction with lung resection presents a safer alternative for managing patients with combined cardiovascular and pulmonary malignancies.
- This strategy may improve patient outcomes by minimizing CPB-related risks and potentially offering a better environment for cancer treatment.
Abstract:
Concomittant severe coronary artery disease and lung malignancies occur rarely. Combined conventional coronary artery bypass grafting (CABG) with the use of cardiopulmonary bypass (CPB) with lung resection posses several perioperative and postoperative problems related to extracorporeal circulation and heparinization. The avoidance of CPB may be advantageous by decreasing blood loss, pulmonary complications and hospital stay. Further, exposure to the immunosuppressive and inflammatory effects of CPB may have deleterious impact on tumor growth and dissemination. Off-pump CABG makes the combined procedure safer as it abolishes the complications of CPB. We report two patients with the diagnosis of severe coronary artery disease and lung malignancies, underwent off-pump CABG and lung resections in the same surgical setting.
