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[Effect of L-dicentrine on contraction of rat stomach muscle strips]

H L Li¹, R P Zhang, H T Ye

¹Department of Pharmacology, Kunming Medical College, Kunming 650031, Yunnan, China.

Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica

|January 8, 2003

Abstract

Objective:

To study the effect of L-dicentrine on the contraction of rat stomach muscle strips induced by 5-HT, histamine K+ and Ca2+.

Method:

In-vitro experimenting on rat stomach muscle strips.

Results:

The contraction of the strips induced by 5-HT histamine K+ and Ca2+ after high K+ depolarization was markedly inhibited by L-dicentrine or papaverine, showing a non-competitive antagonism. The contraction induced by 5-HT was inhibited by L-dicentrine in Ca2+ free solution. L-Dicentrine inhibited the contraction induced by 5-HT, depending on Ca2+ released from the intracellular store. When the Ca2+ concentration in both solutions was restored, L-dicentrine did not influence the contraction significantly.

Conclusion:

L-Dicentrine could relax the rat stomach smooth muscle. In rat stomach smooth muscles there exist 5-HT receptors.

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