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Incomplete anti-Lec, anti-Led, anti-Les (anti-Leb+Led), anti-Lens (anti-Lea+Lec), anti-Lem (anti-Leb+Lec) and anti-Lex (anti-Lea+Leb) antibodies were prepared by the immunization of goats with boiled saliva, absorbing the resulting sera with trypsinized erythrocytes. The discovery (2) of anti-Led which reacts only with Le(a-b-) red cells of secretors, together with an analysis of the theories of GRUBB and CEPPELLINI led the present author to predict the existence of anti-Lec which would react only with Le(a-b-) red cells of non-secretors. GUNSON and LATHAM (1)reported their finding of an antibody fulfilling this latter criterion in the serum of a sample submitted for routine antenatal tests.
Incomplete anti-Lec, anti-Led, anti-Les (anti-Leb+Led), anti-Lens (anti-Lea+Lec), anti-Lem (anti-Leb+Lec) and anti-Lex (anti-Lea+Leb) antibodies were prepared by the immunization of goats with boiled saliva, absorbing the resulting sera with trypsinized erythrocytes. The discovery (2) of anti-Led which reacts only with Le(a-b-) red cells of secretors, together with an analysis of the theories of GRUBB and CEPPELLINI led the present author to predict the existence of anti-Lec which would react only with Le(a-b-) red cells of non-secretors. GUNSON and LATHAM (1)reported their finding of an antibody fulfilling this latter criterion in the serum of a sample submitted for routine antenatal tests.