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[Thyrotoxicosis in heart recipients].

Dorota Skirzyńska1, Mirosław Garlicki, Dariusz Plicner

  • 1Klinika Chirurgii Serca, Naczyń i Transplantologii Instytut Kardiologii Collegium Medicum Uniwersytet Jagielloński, Kraków.

Przeglad Lekarski
|January 9, 2003
PubMed
Summary

Amiodarone can cause thyrotoxicosis in heart transplant patients, leading to complications. One patient died from thyroid crisis post-heart transplantation due to this condition.

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Area of Science:

  • Cardiology
  • Endocrinology
  • Pharmacology

Context:

  • Amiodarone is a common antiarrhythmic drug used in patients awaiting heart transplantation.
  • Thyrotoxicosis is a potential adverse effect of amiodarone therapy.
  • Heart transplantation (HTx) is a critical procedure for end-stage heart failure.

Purpose:

  • To report the incidence and outcomes of amiodarone-induced thyrotoxicosis in patients undergoing heart transplantation.
  • To highlight the potential risks associated with amiodarone use in this patient population.

Summary:

  • Between 1992 and 2000, five patients (4 male, 1 female, average age 45.5 years) developed amiodarone-induced thyrotoxicosis before heart transplantation.
  • Four of these patients underwent orthotopic heart transplantation.

Related Experiment Videos

  • The postoperative period was uncomplicated in patients who achieved euthyroidism; however, one patient died post-HTx due to thyroid crisis.

    • Impact:

    • Amiodarone-induced thyrotoxicosis poses a significant risk in heart transplant candidates.
    • Careful thyroid function monitoring and management are crucial in patients receiving amiodarone before heart transplantation.
    • This highlights the need for multidisciplinary management of thyroid dysfunction in cardiac surgery patients.