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Capillaries in the subarachnoid space.

A Hirano, J Cervós-Navarro, T Ohsugi

    Acta Neuropathologica
    |January 31, 1976
    PubMed
    Summary

    Researchers examined small blood vessels in rat and mouse brains. They identified true capillaries in the subarachnoid space, characterized by a single endothelial cell layer and small lumen.

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    Area of Science:

    • Neuroscience
    • Vascular Biology
    • Histology

    Background:

    • The subarachnoid space contains a network of blood vessels crucial for brain function.
    • Understanding the microvasculature is essential for studying neurological diseases and drug delivery.

    Purpose of the Study:

    • To investigate the fine structure of small blood vessels within the subarachnoid spaces of the rat and mouse cerebral and cerebellar cortices.
    • To identify and characterize the smallest caliber vessels in this region.

    Main Methods:

    • Electron microscopy was utilized to examine the ultrastructure of the microvasculature.
    • Histological analysis focused on the morphology of vessel walls and lumens.

    Main Results:

    • Small vessels with lumens measuring less than 7 micrometers were identified.
    • These vessels were consistently observed to have walls composed of a single layer of endothelial cells.

    Conclusions:

    • The identified small vessels with a single endothelial cell layer and small lumen are classified as true capillaries.
    • This finding contributes to the detailed anatomical understanding of the rodent brain's microvasculature.

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