Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Aminotransferases in post-mortem cochlear fluids.

T Palva, R Nousiainen, V Raunio

    Acta Oto-Laryngologica
    |January 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Effectiveness of screening for colorectal cancer with a faecal occult-blood test, in Finland.

    BMJ open gastroenterology·2015
    Same author

    Effect of exercise on bone structural traits, physical performance and body composition in breast cancer patients--a 12-month RCT.

    Journal of musculoskeletal & neuronal interactions·2012
    Same author

    Effect of supervised and home exercise training on bone mineral density among breast cancer patients. A 12-month randomised controlled trial.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2011
    Same author

    Comparison of pure tones and noise stimuli in sonotubometry.

    Acta oto-laryngologica·2011
    Same author

    Early detection of colorectal cancer with faecal occult blood test screening.

    The British journal of surgery·2010
    Same author

    Apoptosis and regression of embryonic mesenchyme in the development of the middle ear spaces.

    Acta oto-laryngologica·2003
    Same journal

    Vasopressin type-2 receptor mRNA expressions in endolymphatic sac and temporal bone cT findings in Meniere's disease.

    Acta oto-laryngologica·2026
    Same journal

    The impact of climate and environmental factors on the incidence of Bell's palsy: a nationwide population study.

    Acta oto-laryngologica·2026
    Same journal

    Association between low temporalis muscle thickness and chemoradiotherapy-induced leukopenia in head and neck squamous cell carcinoma.

    Acta oto-laryngologica·2026
    Same journal

    Auditory Outcomes After Simultaneous Translabyrinthine Vestibular Schwannoma Resection and Cochlear Implantation: A Prospective Case Series.

    Acta oto-laryngologica·2026
    Same journal

    CT imaging parameters of the oval window region can predict the extent of stapes footplate exposure in patients with otosclerosis.

    Acta oto-laryngologica·2026
    Same journal

    Congenital middle ear anomalies: endoscopic outcomes, facial nerve anomalies, and bilateral consistency in 41 ears.

    Acta oto-laryngologica·2026
    See all related articles

    Aspartate and alanine aminotransferase (ASAT, ALAT) serum levels are significantly elevated in post-mortem samples due to illness. These elevated ASAT and ALAT levels were markedly higher than those found in cerebrospinal fluid and inner ear fluids.

    Area of Science:

    • Biochemistry
    • Neuroscience
    • Clinical Chemistry

    Background:

    • Aspartate aminotransferase (ASAT) and alanine aminotransferase (ALAT) are key enzymes in amino acid metabolism.
    • Elevated serum ASAT and ALAT levels are indicative of liver or heart tissue damage.
    • Understanding enzyme distribution in post-mortem bodily fluids is crucial for interpreting clinical data.

    Purpose of the Study:

    • To quantify and compare ASAT and ALAT activities in human post-mortem sera, cerebrospinal fluid (CSF), perilymph, and endolymph.
    • To investigate the impact of terminal illness on enzyme levels in different biological fluids.

    Main Methods:

    • Analysis of post-mortem human sera, CSF, perilymph, and endolymph.
    • Enzymatic assays to measure ASAT and ALAT activities.

    Related Experiment Videos

    Main Results:

    • ASAT and ALAT serum activities were significantly increased in post-mortem samples from individuals with heart and/or liver morbidity.
    • Serum ASAT and ALAT levels were 20-30 times higher than those observed in CSF and inner ear fluids (p < 0.001).
    • CSF and inner ear fluid samples exhibited similar ASAT and ALAT activity levels.

    Conclusions:

    • Terminal illness significantly elevates serum ASAT and ALAT levels, reflecting tissue damage.
    • CSF and inner ear fluids maintain relatively low and consistent ASAT/ALAT activities compared to serum.
    • These findings highlight the differential distribution of ASAT and ALAT in post-mortem human fluids.