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[Coagulation system and inflammatory bowel disease: therapeutic and pathophysiologic implications]
1Medizinische und Chirurgische Klinik und Poliklinik - Innenstadt, Klinikum der Universität, Ludwig-Maximilians Universität, München. Christian.Folwaczny@medinn.med.uni-muenchen.de
Zeitschrift Fur Gastroenterologie
|January 9, 2003
Summary
Inflammatory bowel disease (IBD) involves haemostatic imbalance, potentially contributing to intestinal pathology. Heparin therapies show promise, suggesting new insights into IBD pathophysiology.
Area of Science:
- Gastroenterology
- Hematology
- Pathophysiology
Background:
- Haemostatic imbalance is linked to inflammatory bowel disease (IBD) pathogenesis.
- A prothrombotic state in Crohn's disease and ulcerative colitis may influence intestinal small vessel changes.
- The causal relationship between coagulation system alterations and systemic inflammation in IBD remains unclear.
Purpose of the Study:
- To explore the association between haemostatic imbalance and inflammatory bowel disease (IBD).
- To investigate the role of prothrombotic states in the pathophysiology of IBD.
- To evaluate the therapeutic potential of heparin in IBD management.
Main Methods:
- Review of existing observations on haemostasis in IBD.
- Analysis of clinical data regarding thrombembolic complications in Crohn's disease and ulcerative colitis.
- Assessment of therapeutic outcomes with unfractionated and low-molecular-weight heparin in active IBD.
Main Results:
- Observations support a connection between haemostatic imbalance and IBD.
- Prothrombotic states appear relevant to intestinal vascular pathology in IBD.
- Heparin demonstrated therapeutic efficacy in patients with active ulcerative colitis and Crohn's disease.
Conclusions:
- Haemostatic alterations are likely integral to IBD pathophysiology.
- Heparin's efficacy suggests a significant role for coagulation in IBD.
- New pathophysiological concepts for IBD are emerging based on these findings.