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Microbial isolates in chronic osteomyelitis--a guide to management.
T O Alonge1, S O Ogunlade, A N Fashina
1Department of Surgery, College of Medicine, University of Ibadan, Ibadan, Nigeria. alonge@skannet.com
African Journal of Medicine and Medical Sciences
|January 10, 2003
Summary
Chronic osteomyelitis treatment is challenging. Staphylococcus aureus is the most common pathogen, with only 30% of isolates sensitive to ceftriaxone and gentamicin.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Orthopedic Surgery
Background:
- Chronic osteomyelitis is a persistent bone infection.
- Effective antibiotic treatment is crucial for managing this condition.
- Identifying causative pathogens and their antibiotic sensitivities is key.
Purpose of the Study:
- To identify common bacterial pathogens in chronic osteomyelitis.
- To determine the antibiotic sensitivity patterns of these isolates.
- To inform treatment strategies for chronic osteomyelitis.
Main Methods:
- Collected effluent and bone biopsies from 60 chronic osteomyelitis patients (1995-1999).
- Performed aerobic and anaerobic cultures.
- Identified bacterial isolates and tested antibiotic sensitivity using antibiotic discs.
Main Results:
- Obtained 47 positive bacterial isolates.
- Staphylococcus aureus was the most frequently isolated organism.
- Only 30% of isolates showed sensitivity to ceftriaxone and gentamicin.
Conclusions:
- Staphylococcus aureus is a primary pathogen in chronic osteomyelitis.
- Limited sensitivity to common antibiotics like ceftriaxone and gentamicin was observed.
- Further research into effective antimicrobial therapies is warranted.