Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Piracetam for acute ischaemic stroke.

S Ricci1, M G Celani, A T Cantisani

  • 1Stroke Service, USL 2, Via Guerra 17, 06127 Perugia, Italy. istitaly@unipg.it

The Cochrane Database of Systematic Reviews
|January 10, 2003
PubMed
Summary

Piracetam may increase early death risk in acute stroke patients, though not statistically significant. More research is needed to determine its effects on long-term dependency and functional outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Real-world influenza surveillance and vaccine effectiveness in children: a multicentre study of the Italian Federation of Primary Care Paediatricians (FIMP).

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2026
Same author

Characterization of fecal bacterial microbiomes according to fecal color, consistency, and sample type in piglets before and after weaning.

Frontiers in veterinary science·2026
Same author

Considering recombinant herpes zoster vaccine for fragile pediatric patients: A new opportunity.

Vaccine·2025
Same author

Wildlife-vehicle collision liability in Europe: A review of existing approaches and their implications.

Journal of environmental management·2025
Same author

How autistic women are aware of their body and take care of their health? Focus on menstruation cycles and gynecological care.

La Clinica terapeutica·2024
Same author

Parents-children co-regulation as therapeutic variable and target in autism spectrum disorders. From observation of drive to need of cooperative parent-mediated therapy.

La Clinica terapeutica·2023

Area of Science:

  • Neurology
  • Pharmacology
  • Clinical Trials

Background:

  • Piracetam exhibits neuroprotective and antithrombotic properties.
  • These effects suggest potential benefits in reducing mortality and disability following acute stroke.

Purpose of the Study:

  • To systematically review and assess the efficacy of piracetam in managing acute ischemic stroke.
  • Evaluate piracetam's impact on mortality, functional outcomes, and dependency in stroke patients.

Main Methods:

  • Conducted a comprehensive literature search across multiple databases (Cochrane, MEDLINE, EMBASE) and handsearched journals.
  • Included randomized controlled trials comparing piracetam with placebo in acute stroke patients (within 48 hours of onset).
  • Data extraction and quality assessment were performed by multiple reviewers, with efforts to obtain missing information from study authors.

Related Experiment Videos

Main Results:

  • Three trials with 1002 participants were analyzed; one trial dominated the data.
  • Piracetam showed a non-significant trend towards increased early mortality, potentially influenced by baseline stroke severity.
  • No significant differences were observed in functional outcomes or dependency between piracetam and control groups.

Conclusions:

  • A potential unfavorable effect of piracetam on early mortality is suggested but not statistically confirmed.
  • Baseline differences in stroke severity may have confounded the observed mortality trend.
  • Insufficient evidence exists to determine piracetam's impact on patient dependency after stroke.