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Related Experiment Videos

Nitrates for achalasia.

Z H Wen1, E Gardener, Y P Wang

  • 1Department of Gastroenterology, West China Hospital of Sichuan University, Guo Xue Xiang 37#, Chengdu, China, 610041. amyw@21cn.com

The Cochrane Database of Systematic Reviews
|January 10, 2003
PubMed
Summary
This summary is machine-generated.

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The effectiveness of nitrate therapy for achalasia remains uncertain due to a lack of sufficient evidence. More rigorous, long-term randomized controlled trials are required to determine the true impact of nitrates on esophageal motility disorders.

Area of Science:

  • Gastroenterology
  • Pharmacology

Background:

  • Achalasia is a disorder affecting esophageal motility.
  • The efficacy of nitrates for treating achalasia is debated despite historical use.

Purpose of the Study:

  • To evaluate the short-term and long-term effectiveness of nitrate therapy in achalasia patients.

Main Methods:

  • Systematic search of multiple databases (Cochrane, MEDLINE, EMBASE, LILACS, CBM) and reference checking.
  • Inclusion of all randomized controlled trials (RCTs) involving achalasia patients treated with nitrates.
  • Data extraction by two independent observers using the intention-to-treat principle.

Main Results:

  • Two randomized cross-over studies were identified.

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  • Results could not be extracted due to study design and reporting methods.
  • Insufficient data prevented the examination of any outcomes.

    • Conclusions:

    • Current evidence does not support clinical practice changes regarding nitrate use for achalasia.
    • There is a need for well-designed, parallel-group RCTs with long-term follow-up to ascertain nitrate effects.