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Related Experiment Videos

Interventions for treating collagenous colitis.

N Chande1, J W McDonald, J K MacDonald

  • 1c/o 5-OF 12 LHSC-UC, 339 Windermere Road, London, Ontario, Canada, N6A 5A5. nchande@uwo.ca

The Cochrane Database of Systematic Reviews
|January 10, 2003
PubMed
Summary
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Budesonide effectively treats collagenous colitis, showing significant clinical and histological improvement. Bismuth subsalicylate also shows promise for this chronic diarrhea disorder.

Area of Science:

  • Gastroenterology
  • Pharmacology
  • Clinical Trials

Background:

  • Collagenous colitis is a recognized cause of chronic diarrhea.
  • Current treatment strategies for collagenous colitis largely rely on anecdotal evidence.
  • This review aimed to identify therapies with proven efficacy through randomized trials.

Purpose of the Study:

  • To determine effective treatment options for patients experiencing active collagenous colitis.
  • To evaluate the evidence from randomized controlled trials for collagenous colitis therapies.

Main Methods:

  • A comprehensive literature search was conducted using MEDLINE, PUBMED, and EMBASE databases (1970-2002).
  • Manual searches of references, review papers, and conference abstracts supplemented database searches.

Related Experiment Videos

  • Four randomized trials were identified, focusing on bismuth subsalicylate and budesonide.

    • Main Results:

    • Bismuth subsalicylate demonstrated significant clinical and histological improvement in a small trial (p=0.003).
    • Budesonide showed a pooled odds ratio of 16.79 (95% CI 7.28-38.74) for clinical response in 86 patients across three trials.
    • Budesonide therapy resulted in significant histological improvement in all included trials, with a number needed to treat of 2.

    Conclusions:

    • Budesonide is an effective treatment for collagenous colitis, demonstrating robust clinical and histological benefits.
    • Evidence for bismuth subsalicylate, while weaker, suggests it is an important therapeutic option.
    • The efficacy of these and other therapies in inducing or maintaining remission remains to be determined.