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Related Experiment Videos

Terazosin for benign prostatic hyperplasia.

T J Wilt1, R W Howe, I R Rutks

  • 1General Internal Medicine (111-0), Minneapolis VA/VISN 13 Center for Chronic Disease Outcomes Research, One Veterans Drive, Minneapolis, Minnesota 55417, USA. Tim.Wilt@med.va.gov

The Cochrane Database of Systematic Reviews
|January 10, 2003
PubMed
Summary
This summary is machine-generated.

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See all related articles

Terazosin effectively treats benign prostatic obstruction (BPO) symptoms and improves urine flow compared to placebo and finasteride. However, it has more side effects than other alpha-blockers, leading to increased discontinuation.

Area of Science:

  • Urology
  • Pharmacology

Background:

  • Benign prostatic obstruction (BPO) affects up to 70% of men over 60.
  • Lower urinary tract symptoms (LUTS) are common in BPO.
  • Alpha-blockers are a primary treatment for BPO symptoms.

Purpose of the Study:

  • To systematically review the effectiveness and adverse effects of terazosin for BPO.
  • To compare terazosin with placebo and other BPO treatments.

Main Methods:

  • Systematic review of randomized controlled trials.
  • Included studies compared terazosin to placebo or active controls for at least 1 month.
  • Data extracted included symptom scores, urodynamic measures, and adverse effects.

Main Results:

Related Experiment Videos

  • Terazosin improved symptom scores (Boyarsky, AUA, IPSS) and flow rates more than placebo and finasteride.
  • Effectiveness was similar to other alpha-blockers but less than TUMT.
  • Adverse effects (dizziness, hypotension) were more frequent than placebo, increasing discontinuation rates.

    • Conclusions:

    • Terazosin is effective for BPO symptoms and flow.
    • It offers superior efficacy to placebo and finasteride.
    • Higher adverse event rates necessitate careful consideration due to increased discontinuation.