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Related Experiment Videos

A supercritical fluid-based coating technology 1: process considerations.

C Thies1, I Ribeiro Dos Santos, J Richard

  • 1Biological Transport Laboratory, Washington University, Campus Box 1198, St Louis, MO 63130-4899, USA.

Journal of Microencapsulation
|January 10, 2003
PubMed
Summary
This summary is machine-generated.

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A new particle coating method uses supercritical fluids (SCF) to deposit materials onto particles. This solvent-free technique offers tunable coating morphologies for applications in pharmaceuticals and food science.

Area of Science:

  • Materials Science
  • Chemical Engineering
  • Pharmaceutical Technology

Background:

  • Traditional particle coating methods often involve organic solvents, posing environmental and safety concerns.
  • Supercritical fluids (SCF) offer tunable solvent properties and environmentally benign processing advantages.
  • Developing solvent-free coating techniques is crucial for sustainable manufacturing in various industries.

Purpose of the Study:

  • To describe a novel solvent-free particle coating process utilizing supercritical fluids.
  • To investigate the feasibility of coating different materials onto particles using this SCF-based method.
  • To analyze the resulting coating morphologies based on the properties of the coating materials.

Main Methods:

  • Dissolving coating materials in supercritical carbon dioxide (CO2).

Related Experiment Videos

  • Adjusting temperature and pressure to induce insolubilization and deposition of coating material.
  • Applying the process to bovine serum albumin and sugar granules using trimyristin and Gelucire 50/02 as coating agents.

    • Main Results:

    • Effective particle coating was achieved using the supercritical fluid process.
    • Coating morphology varied significantly with the coating material.
    • Trimyristin resulted in a discontinuous, micro-needle-like coating.
    • Gelucire 50/02 formed a smooth, regular, film-like coating.

    Conclusions:

    • The described supercritical fluid process is a viable solvent-free method for particle coating.
    • The process allows for control over coating morphology by selecting appropriate coating materials.
    • This technique holds promise for applications requiring tailored particle surface modification.