Related Experiment Video
Updated: Jul 24, 2026
11:13
RNA-Seq Analysis of Differential Gene Expression in Electroporated Chick Embryonic Spinal Cord
Published on: November 1, 2014
Ensembl 2002: accommodating comparative genomics
1The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.
Nucleic Acids Research
|January 10, 2003
Summary
The Ensembl database offers a comprehensive bioinformatics framework for organizing biological data around genome sequences. It provides stable, automatic annotation for human, mouse, and other genomes, supporting research worldwide.
Area of Science:
- Bioinformatics
- Genomics
- Computational Biology
Background:
- The Ensembl database project provides a bioinformatics framework for organizing biological data around large genome sequences.
- It serves as a comprehensive source for stable, automatic annotation of human, mouse, and other genome sequences.
- Ensembl also integrates manually annotated gene structures from external sources.
Purpose of the Study:
- To present the Ensembl database project as a bioinformatics framework for genome sequence organization and annotation.
- To highlight Ensembl's role as a comprehensive source of stable automatic annotation for various genome sequences.
- To showcase Ensembl's development as an open-source software engineering project for handling large genomes.
Main Methods:
- Utilizing a bioinformatics framework to organize biological data around genome sequences.
- Providing stable automatic annotation for human, mouse, and other genome sequences.
- Integrating manually annotated gene structures from external sources.
Main Results:
- Ensembl offers an interactive website and flat files for accessing genome annotation data.
- It functions as an open-source software engineering project for managing large genomes.
- Developments focus on automatic comparative genome analysis and visualization for vertebrate genomes.
Conclusions:
- Ensembl is a vital resource for genome annotation and bioinformatics research.
- Its open-source nature and global installations facilitate widespread use in academic and commercial settings.
- Ongoing developments enhance comparative genomics capabilities, particularly for vertebrate species.
More Related Videos
10:40Comprehensive Workflow for the Genome-wide Identification and Expression Meta-analysis of the ATL E3 Ubiquitin Ligase Gene Family in Grapevine
Published on: December 22, 2017
08:03Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
Published on: December 7, 2021
Related Concept Videos
00:58Genomic DNA in Eukaryotes
Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.
02:02Genomics
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
02:16Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes
The present-day mitochondrial and chloroplast genomes have retained some of the characteristics of their ancestral prokaryotes and also have acquired new attributes during their evolution within eukaryotic cells. Like prokaryotic genomes, mitochondrial and chloroplast genomes neither bind with histone-like proteins nor show complex packaging into chromosome-like structures, as observed in eukaryotes. Unlike mitotic cell divisions observed in eukaryotic cells, mitochondria and chloroplasts...
02:54Evolutionary Relationships through Genome Comparisons
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
02:51Multi-species Conserved Sequences
Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale studies have provided new insights into the evolutionary relationship between organisms.
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved DNA...
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved DNA...
03:36Genome Annotation and Assembly
The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.