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An improved version of the DNA Methylation database (MethDB).

Céline Amoreira1, Winfried Hindermann, Christoph Grunau

  • 1Institut de Génétique Humaine, CNRS UPR 1142, Laboratoire de Séquences Répétées et Centromères Humains, 141 Rue de la Cardonille, 34396 Montpellier, France.

Nucleic Acids Research
|January 10, 2003
PubMed
Summary

DNA methylation, specifically 5-methylcytosine (5mC) in eukaryotes, is crucial for development and linked to cancer. MethDB is a public database consolidating DNA methylation data for 46 species.

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Area of Science:

  • Epigenetics
  • Genomics
  • Molecular Biology

Background:

  • Cytosine methylation is a fundamental epigenetic modification in prokaryotic and eukaryotic genomes.
  • Aberrant 5-methylcytosine (5mC) patterns are implicated in severe disorders, notably cancer.
  • Significant scientific interest necessitates accessible data on this epigenetic phenomenon.

Purpose of the Study:

  • To establish and maintain a comprehensive, publicly accessible database for DNA methylation data.
  • To centralize methylation patterns, profiles, and total methylation content from diverse species and experiments.
  • To facilitate data sharing and accessibility for the research community.

Main Methods:

  • Development of the DNA Methylation database (MethDB).
  • Data compilation from 6667 experiments covering 46 species, 160 tissues, and 72 phenotypes.

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  • Implementation of an online submission tool for public data contribution.

    • Main Results:

    • MethDB is the sole public repository for DNA methylation data.
    • The database contains extensive data for 46 species, 160 tissues, and 72 phenotypes.
    • Approximately 14% of the data are unpublished, offering novel insights.

    Conclusions:

    • MethDB serves as a vital, continuously expanding resource for DNA methylation research.
    • The database enhances data accessibility and promotes collaborative research in epigenetics.
    • The integrated online submission tool supports the growth and comprehensiveness of the resource.