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Related Experiment Videos

RECODE 2003.

Pavel V Baranov1, Olga L Gurvich, Andrew W Hammer

  • 1Department of Human Genetics, University of Utah, 15N 2030E Room 7410, Salt Lake City, UT 84112-5330, USA.

Nucleic Acids Research
|January 10, 2003
PubMed
Summary
This summary is machine-generated.

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The RECODE database catalogs translational recoding events, including programmed ribosomal frameshifting and codon redefinition. It offers crucial data on gene expression mechanisms and regulatory elements for researchers.

Area of Science:

  • Molecular Biology
  • Genetics
  • Bioinformatics

Background:

  • Translational recoding events modify gene expression at the ribosome level.
  • These events, such as programmed ribosomal frameshifting and codon redefinition, are critical for regulating protein synthesis.
  • Understanding these mechanisms is essential for comprehending gene expression complexity.

Purpose of the Study:

  • To compile and present a comprehensive database of translational recoding events.
  • To provide detailed information on genes, recoding sites, and regulatory elements involved in these events.
  • To make this valuable resource freely accessible to the scientific community.

Main Methods:

  • Data compilation from scientific literature.
  • Information categorization including genes, recoding sites, and stimulatory sequences.

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  • Database development and web accessibility.

    • Main Results:

    • The RECODE database successfully integrates diverse translational recoding events.
    • It offers a centralized resource for studying programmed ribosomal frameshifting, codon redefinition, and translational bypass.
    • The database includes specific examples of genes and their associated recoding mechanisms.

    Conclusions:

    • The RECODE database serves as a vital resource for researchers investigating gene expression.
    • It facilitates the study of complex translational control mechanisms.
    • The free availability of RECODE promotes further research in molecular biology and genetics.