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ASAP: the Alternative Splicing Annotation Project.

Christopher Lee1, Levan Atanelov, Barmak Modrek

  • 1Molecular Biology Institute, Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095-1570, USA. leec@mbi.ucla.edu

Nucleic Acids Research
|January 10, 2003
PubMed
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Alternative splicing is common in mammals and regulated by gene isoforms. The Alternative Splicing Annotation Project (ASAP) database provides a resource for studying alternative splicing, its regulation, and functions.

Area of Science:

  • Genomics
  • Bioinformatics
  • Molecular Biology

Background:

  • Alternative splicing is a widespread mechanism in mammalian genomes, generating multiple gene isoforms and regulating gene function.
  • Existing genomic databases lack comprehensive infrastructure for alternative splicing data analysis.
  • Genomics and proteomics studies are generating vast amounts of alternative splicing information.

Purpose of the Study:

  • To develop an accessible online database, ASAP (Alternative Splicing Annotation Project), for biologists.
  • To provide a centralized resource for mining and analyzing alternative splicing information.
  • To facilitate collaborative annotation of alternative splice forms, their regulation, and biological functions.

Main Methods:

  • Genome-wide analysis of alternative splicing in humans.

Related Experiment Videos

  • Detailed alignment of expressed sequences to genomic sequences.
  • Development of the ASAP online database infrastructure.

    • Main Results:

    • Identification of 30,793 alternative splice relationships in the human genome.
    • ASAP provides precise gene exon-intron structures and protein isoform sequences.
    • Tissue specificity of alternative splice forms is detailed within the database.

    Conclusions:

    • ASAP serves as a valuable community resource for alternative splicing research.
    • The database aids in designing probe sequences for specific mRNA isoforms.
    • ASAP supports the study of alternative splicing regulation and biological functions.