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InterDom: a database of putative interacting protein domains for validating predicted protein interactions and
See-Kiong Ng1, Zhuo Zhang, Soon-Heng Tan
1Biocomputing Group, Laboratories for Information Technology, 21 Heng Mui Keng Terrace, 119613 Singapore Genome Institute of Singapore, 1 Science Park Road, 05-01, 117528 Singapore. skng@lit.a-star.edu.sg
Nucleic Acids Research
|January 10, 2003
Summary
The InterDom database supports protein interaction discovery by analyzing protein domain interactions. It integrates data from multiple sources to validate and annotate protein complex findings.
Area of Science:
- Proteomics
- Bioinformatics
- Computational Biology
Background:
- High-throughput proteomics methods accelerate protein discovery and interaction detection.
- Data-driven approaches generate large datasets that require validation and annotation.
- Protein domain interactions are crucial for understanding protein complex formation.
Purpose of the Study:
- To introduce the InterDom database, a resource for supporting protein interaction evidence.
- To focus on validating protein interactions using putative protein domain interactions.
- To provide a centralized platform for accessing protein domain interaction data.
Main Methods:
- Utilizing an integrative approach to derive potential domain interactions.
- Combining data from multiple sources including domain fusions and protein complexes.
- Leveraging scientific literature for additional supporting evidence.
Main Results:
- The InterDom database provides supporting evidence for detected protein interactions.
- It identifies potential domain interactions by integrating diverse data types.
- The database facilitates the validation and annotation of high-throughput proteomics data.
Conclusions:
- InterDom enhances the reliability of protein interaction data through domain interaction analysis.
- The database serves as a valuable resource for researchers in proteomics and systems biology.
- Integrating multiple data sources improves the accuracy and scope of protein interaction evidence.