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GPCRDB information system for G protein-coupled receptors
Florence Horn1, Emmanuel Bettler, Laerte Oliveira
1Department of Cellular and Molecular Pharmacology, UCSF, San Francisco, California, USA.
Nucleic Acids Research
|January 10, 2003
Summary
The G protein-coupled receptors database (GPCRDB) is a comprehensive system for G protein-coupled receptors (GPCRs) data. It offers validated sequences, binding affinities, and mutation information for researchers.
Area of Science:
- Biochemistry
- Pharmacology
- Bioinformatics
Background:
- G protein-coupled receptors (GPCRs) represent a vast superfamily of cell surface receptors.
- GPCRs are crucial drug targets, involved in numerous physiological processes.
- A centralized, validated data resource for GPCRs is essential for research advancement.
Purpose of the Study:
- To present the GPCRDB, a molecular class-specific information system for G protein-coupled receptors.
- To consolidate and disseminate heterogeneous data related to GPCRs.
- To provide researchers with tools for querying and visualizing GPCR data.
Main Methods:
- Data collection, combination, and validation from heterogeneous sources.
- Integration of experimental data (sequences, binding constants, mutations).
- Inclusion of computationally derived data (sequence alignments, homology models).
Main Results:
- The GPCRDB provides a curated repository of GPCR information.
- The system includes experimental and in silico data for over 7TM receptors.
- Automated updates ensure data relevance, occurring every 4-5 months.
Conclusions:
- The GPCRDB serves as a valuable, freely accessible resource for the scientific community.
- It facilitates research on G protein-coupled receptors through integrated data and tools.
- The database supports drug discovery and a deeper understanding of GPCR function.