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Related Experiment Videos

Human immunodeficiency virus reverse transcriptase and protease sequence database.

Soo-Yon Rhee1, Matthew J Gonzales, Rami Kantor

  • 1Division of Infectious Diseases, Department of Medicine, Stanford University, Stanford, CA 94305, USA.

Nucleic Acids Research
|January 10, 2003
PubMed
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The HIV sequence database tracks variations in reverse transcriptase and protease, crucial for antiretroviral therapy. This resource aids in understanding drug resistance and viral evolution in human immunodeficiency virus (HIV).

Area of Science:

  • Virology
  • Molecular Biology
  • Bioinformatics

Background:

  • Antiretroviral therapy targets human immunodeficiency virus (HIV) reverse transcriptase (RT) and protease enzymes.
  • Understanding sequence variation in these enzymes is critical for effective HIV treatment.
  • Existing databases may not fully capture the breadth of published and clinical HIV sequence data.

Purpose of the Study:

  • To establish an online relational database cataloguing evolutionary and drug-related sequence variation in HIV RT and protease.
  • To link sequence data with clinical information, including antiretroviral drug treatment history and in vitro drug susceptibility testing results.
  • To provide a comprehensive resource for researchers studying HIV drug resistance and evolution.

Main Methods:

Related Experiment Videos

  • Compilation of nearly all published HIV RT and protease sequences from GenBank, journal articles, and clinical trials.
  • Development of an on-line relational database structure to store and link sequence data.
  • Integration of metadata including sequence source, patient treatment history, and drug susceptibility data.

    • Main Results:

    • Creation of a comprehensive online database of HIV reverse transcriptase and protease sequences.
    • Successful linkage of sequence data with critical clinical and drug resistance information.
    • Planned expansion to include new HIV drug targets such as gp41 and integrase.

    Conclusions:

    • The HIV RT and protease sequence database serves as a valuable resource for studying HIV evolution and drug resistance.
    • The database facilitates research into the molecular targets of antiretroviral therapy.
    • Future additions will enhance the database's utility for understanding emerging HIV drug resistance mechanisms.