Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

SDAP: database and computational tools for allergenic proteins.

Ovidiu Ivanciuc1, Catherine H Schein, Werner Braun

  • 1Sealy Center for Structural Biology, Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, 310 University Boulevard, Galveston, TX 77555-1157, USA.

Nucleic Acids Research
|January 10, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

AllergenAI: a deep learning model predicting allergenicity based on protein sequence.

BMC bioinformatics·2025
Same author

Sequences and Structures of Viral Proteins Linked to the Genomes (VPg) of RNA Viruses.

Viruses·2025
Same author

Fine resolution of the N-terminal IgE-binding epitope of Ara h 2: Discovery of variants with enhanced IgE binding.

The Journal of allergy and clinical immunology·2025
Same author

AllergenAI: a deep learning model predicting allergenicity based on protein sequence.

bioRxiv : the preprint server for biology·2024
Same author

Displaying alphavirus physicochemical consensus antigens on immunogenic liposomes enhances antibody elicitation in mice.

Virology·2024
Same author

The updated Structural Database of Allergenic Proteins (SDAP 2.0) provides 3D models for allergens and incorporated bioinformatics tools.

The journal of allergy and clinical immunology. Global·2023
Same journal

Correction to 'scSuperAnnotator: A platform for benchmarking comparison and visualizing automated cellular annotation methods for scRNA-seq data'.

Nucleic acids research·2026
Same journal

Correction to 'Differentiable partition function calculation for RNA'.

Nucleic acids research·2026
Same journal

Deployment of non-canonical splicing in tunicate genomes is mediated by divergent U2AF function and changing m6A modification in U1 and U6 snRNA.

Nucleic acids research·2026
Same journal

Bacillus subtilis DnaB forms multiple protein-protein interactions essential for DNA replication initiation.

Nucleic acids research·2026
Same journal

Multiple forms of protein-protein and DNA binding are exhibited by BrxC from the BREX phage restriction system.

Nucleic acids research·2026
Same journal

Biosynthesis of glycosylated 5-hydroxycytosine in the DNA of diverse viruses.

Nucleic acids research·2026
See all related articles

The Structural Database of Allergenic Proteins (SDAP) offers quick access to allergen data, including sequences and IgE epitopes. This bioinformatics tool aids in identifying cross-reactivities and screening for allergenic epitopes.

Area of Science:

  • Bioinformatics
  • Immunology
  • Structural Biology

Background:

  • Allergenic proteins pose significant health risks.
  • Understanding allergen structure and epitopes is crucial for diagnostics and therapeutics.
  • Existing databases may lack comprehensive, integrated data on allergenic proteins.

Purpose of the Study:

  • To develop and present the Structural Database of Allergenic Proteins (SDAP) web server.
  • To provide a centralized resource for allergenic protein sequences, structures, and IgE epitopes.
  • To facilitate the identification of potential allergen cross-reactivities and screening of novel proteins for epitopes.

Main Methods:

  • Development of a web server utilizing CGI scripts for data retrieval and computation.
  • Integration of data from major protein and literature databases (PDB, SWISS-PROT, PubMed, etc.).

Related Experiment Videos

  • Implementation of an original algorithm for identifying conserved amino acid properties in allergenic regions and IgE epitopes.

    • Main Results:

    • SDAP provides rapid, cross-referenced access to comprehensive allergenic protein information.
    • The database includes allergen name, source, sequence, structure, IgE epitopes, and literature references.
    • The computational component enables identification of similar regions in known allergens and screening for potential IgE epitopes.

    Conclusions:

    • SDAP serves as a valuable bioinformatics tool for researchers studying allergies.
    • The server facilitates the prediction of cross-reactivity between allergens.
    • SDAP aids in the discovery and characterization of novel allergenic epitopes.