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SRPDB: Signal Recognition Particle Database.

Magnus Alm Rosenblad1, Jan Gorodkin, Bjarne Knudsen

  • 1Department of Medical Biochemistry, University of Göteborg, Box 440, SE-405 30 Göteborg, Sweden.

Nucleic Acids Research
|January 10, 2003
PubMed
Summary
This summary is machine-generated.

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The Signal Recognition Particle Database (SRPDB) aids understanding of SRP structure and function. It now includes a relational database and prediction server for identifying SRP RNAs and their structures.

Area of Science:

  • Molecular Biology
  • Bioinformatics
  • Structural Biology

Background:

  • The Signal Recognition Particle (SRP) is a crucial ribonucleoprotein complex.
  • SRP mediates protein targeting by recognizing signal sequences emerging from ribosomes.

Purpose of the Study:

  • To enhance the understanding of Signal Recognition Particle (SRP) structure and function.
  • To provide a comprehensive, updated resource for SRP RNA and protein sequences.

Main Methods:

  • Compilation and organization of SRP RNA and protein sequences.
  • Comparative sequence analysis to derive accurate SRP RNA secondary structures.
  • Introduction of a relational database system and a SRP RNA prediction server (SRP-Scan).

Main Results:

Related Experiment Videos

  • The database now contains 181 SRP RNA sequences and numerous SRP protein sequences (SRP9, SRP14, SRP19, SRP54, SRP68, SRP72).
  • Includes 99 entries for the SRP receptor alpha subunit and FtsY homolog, plus data for related polypeptides.
  • New features include a relational database and the SRP-Scan server for SRP RNA identification and secondary structure prediction.

Conclusions:

  • SRPDB serves as a valuable resource for researchers studying SRP-mediated protein targeting.
  • The new SRP-Scan server facilitates the discovery and structural analysis of novel SRP RNAs.
  • The database advancements improve accessibility and utility for exploring SRP biology.