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Related Experiment Videos

The Protein Data Bank and structural genomics.

John Westbrook1, Zukang Feng, Li Chen

  • 1Research Collaboratory for Structural Bioinformatics, Rutgers, The State University of New Jersey, Department of Chemistry and Chemical Biology, 610 Taylor Road, Piscataway, NJ 08854-8087, USA.

Nucleic Acids Research
|January 10, 2003
PubMed
Summary
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The Protein Data Bank (PDB) supports structural genomics by managing target registration and developing data standards. They create software tools for efficient data capture and deposition in structural biology.

Area of Science:

  • Structural Biology
  • Bioinformatics
  • Computational Biology

Background:

  • Structural genomics projects aim to determine the three-dimensional structures of proteins on a large scale.
  • The Protein Data Bank (PDB) is a crucial resource for archiving and disseminating structural data.
  • Effective informatics infrastructure is essential for the success of structural genomics initiatives.

Purpose of the Study:

  • To outline the PDB's ongoing contributions to structural genomics informatics.
  • To highlight the development and maintenance of key databases and tools.
  • To emphasize the PDB's role in standardizing data exchange within the structural biology community.

Main Methods:

  • Development and maintenance of the Target Registration Database (TargetDB).

Related Experiment Videos

  • Organization of data dictionaries for standardized data exchange.
  • Creation of software tools for capturing structure determination data.

    • Main Results:

    • Active involvement of the PDB in critical informatics aspects of structural genomics.
    • Establishment of a centralized system for registering structural genomics targets.
    • Development of standardized formats for data deposition and exchange.

    Conclusions:

    • The PDB plays a vital role in advancing structural genomics through informatics support.
    • Standardized data management and tools facilitate large-scale structure determination efforts.
    • Continued PDB involvement ensures data integrity and accessibility for the scientific community.