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Leptin inhibits food intake without affecting brain NOx levels in food-deprived mice

Yumi Sugimoto1, Hiroshi Hirose, Tatsuo Yagura

  • 1Department of Pharmacology, Kobe Pharmaceutical University, 4-19-1 Motoyamakita-machi, Higashinada-ku, Kobe 658-8558, Japan. yumisugi@kobepharma-u.ac.jp

Biological & Pharmaceutical Bulletin
|January 10, 2003
PubMed

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Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...