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Related Experiment Videos

Huntington's chorea associated with normal pressure hydrocephalus.

B H Tang, A Lieberman, R Rovit

    European Neurology
    |January 1, 1975
    PubMed
    Summary

    This study reports two patients with Huntington's chorea (HC) who also presented with normal pressure hydrocephalus (NPH). Shunt treatment improved both gait and involuntary movements, suggesting a potential link between these conditions.

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    Area of Science:

    • Neurology
    • Neurosurgery
    • Movement Disorders

    Background:

    • Huntington's chorea (HC) is a neurodegenerative disorder characterized by abnormal involuntary movements (AIMs).
    • Normal pressure hydrocephalus (NPH) is a neurological condition typically presenting with gait disturbance, urinary incontinence, and cognitive impairment.

    Purpose of the Study:

    • To investigate the co-occurrence of Huntington's chorea and normal pressure hydrocephalus in two patients.
    • To evaluate the effect of NPH treatment on both gait disturbance and choreiform movements.

    Main Methods:

    • Clinical assessment of two patients with suspected HC and NPH.
    • Diagnostic confirmation using pneumoencephalography and isotope cisternography.
    • Surgical intervention with shunting for NPH.

    Main Results:

    • Both patients exhibited gait disturbances initially suggestive of NPH.
    • Shunt placement led to significant improvement in gait.
    • Unexpectedly, shunt treatment also resulted in a reduction of abnormal involuntary movements (AIMs) in both patients.

    Conclusions:

    • The findings suggest a potential association between Huntington's chorea and normal pressure hydrocephalus.
    • Treatment for NPH may offer benefits beyond gait improvement, potentially impacting choreiform movements in co-occurring HC.

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