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Updated: Sep 27, 2026

Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma
Published on: October 27, 2014
Combining bioreductive drugs and radiation for the treatment of solid tumors
Ian J Stratford1, Kaye J Williams, Rachel L Cowen
1School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, UK.
Abstract:
Methods now exist for the identification of human tumors that contain significant numbers of hypoxic cells and are thereby suitable for treatment with bioreductive drugs to eliminate this refractory cell population. However, to fully exploit the potential of bioreductive drugs, they will need to be used in combination with other modalities likely to target the proliferating aerobic cells in the tumor. Radiation is the treatment that is most effective in killing aerobic cells; therefore, the present report reviews the available preclinical data on combined radiation/bioreductive drug treatments.
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