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Related Experiment Videos

Vitamin D: A millenium perspective.

Michael F Holick1

  • 1Vitamin D Laboratory, Section of Endocrinology, Department of Medicine, Boston University Medical Center, Boston, Massachusetts 02118, USA. mfholick@bu.edu

Journal of Cellular Biochemistry
|January 10, 2003
PubMed
Summary
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Vitamin D is crucial for calcium absorption and bone health. Deficiency can lead to serious health issues, including osteoporosis and increased cancer risk.

Area of Science:

  • Endocrinology
  • Cell Biology
  • Nutritional Science

Background:

  • Vitamin D, an ancient hormone, is synthesized by various organisms upon sun exposure.
  • It plays a vital role in skeletal development and calcium homeostasis throughout life.
  • Vitamin D metabolism involves liver and kidney conversion to 1,25-dihydroxyvitamin D [1,25(OH)(2)D].

Purpose of the Study:

  • To highlight the fundamental importance of vitamin D in calcium absorption and bone health.
  • To underscore the widespread presence of vitamin D receptors (VDR) in various tissues beyond bone.
  • To emphasize the potential adverse health consequences of chronic vitamin D deficiency.

Main Methods:

  • Review of vitamin D's role in calcium homeostasis and bone metabolism.
Keywords:
Non-programmatic

Related Experiment Videos

  • Examination of 1,25(OH)(2)D's cellular functions, including antiproliferative and differentiation effects.
  • Analysis of the association between vitamin D deficiency and various chronic diseases.

    • Main Results:

    • Vitamin D enhances intestinal calcium absorption and regulates bone remodeling.
    • 1,25(OH)(2)D exhibits potent effects on cell proliferation and differentiation across multiple tissues.
    • Vitamin D deficiency is linked to rickets, osteomalacia, osteoporosis, and increased risks of hypertension, MS, and cancers.

    Conclusions:

    • Vitamin D is essential for skeletal health and calcium balance.
    • The extraskeletal functions of vitamin D are significant, impacting various cellular processes.
    • Recognizing and addressing vitamin D deficiency is critical for public health and disease prevention.