[Effect of estrogen on the expression of c-myc protein of bone in mice]

In order to study the mechanism by which estrogen effects on bone, the effect of estrone on expression of c-myc protein in the epiphyseal plate of fetal mouse long bone was detected by immunohistochemistry procedure in vitro. The result showed that the concentrations of estrone areas of positively staining cells increased significantly in proliferative zone at 10(-9) mol/L, in proliferative zone and resting zone at 10(-8) mol/L, and in resting zone, proliferative zone and hypertrophic zone at 10(-7) mol/L respectively. It was considered that estrogen might enforce endochondral bone formation by enhancing expression of c-myc in long bone.