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[Fibrinogen: cardiovascular risk factor]

Raúl A Espinosa1,

  • 1Unidad de Cardiología, Hospital Miguel Pérez Carreño, Caracas, Venezuela. espvar@cantv.net

Investigacion Clinica
|January 11, 2003
PubMed

Insights

Plasmatic fibrinogen is a significant risk factor for ischemic cardiovascular disease. Elevated fibrinogen levels predict cardiovascular events, highlighting its role in atherothrombosis and disease prevention.

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Epidemiology

Context:

  • Plasminogen fibrinogen is implicated in atherothrombosis beyond its hemostatic role.
  • Prospective studies indicate plasminogen fibrinogen as a predictor of cardiovascular events in diverse populations.
  • A pilot epidemiological study in Venezuela addresses Latin American populations, distinct from prior research settings.

Purpose:

  • To demonstrate plasmatic fibrinogen as a risk factor for ischemic cardiovascular disease.
  • To review the role of fibrinogen in atherothrombosis and cardiovascular event prediction.
  • To explore factors influencing fibrinogen levels and their potential for disease prevention.

Summary:

  • Plasmatic fibrinogen is identified as a key risk factor for ischemic cardiovascular disease.
  • Evidence from prospective studies confirms fibrinogen's predictive value for cardiovascular events, including recurrence.
  • An epidemiological study in Venezuela is presented as a pilot for Latin America, considering population-specific factors.

Impact:

  • Findings underscore the importance of fibrinogen levels in cardiovascular risk assessment.
  • Identifies modifiable factors influencing fibrinogen, suggesting potential preventive strategies.
  • Highlights the need for further research into the therapeutic benefits of controlling fibrinogen levels for cardiovascular disease prevention.

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