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Related Experiment Videos

Antioxidant status in thyroid dysfunction.

Ulrike Resch1, Gwen Helsel, Franz Tatzber

  • 1Department of Nuclear Medicine, University of Vienna, Vienna, Austria.

Clinical Chemistry and Laboratory Medicine
|January 11, 2003
PubMed
Summary
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Thyroid disorders like hyperthyroidism and hypothyroidism increase oxidative stress. Hypothyroid patients showed higher anti-oxidized LDL antibody titers, suggesting increased atherosclerosis risk.

Area of Science:

  • Endocrinology
  • Biochemistry
  • Oxidative Stress Research

Background:

  • Thyroid dysfunction, including hyperthyroidism and hypothyroidism, significantly impacts metabolic processes.
  • Oxidative stress is implicated in various chronic diseases, but its specific role in thyroid disorders requires further elucidation.

Purpose of the Study:

  • To compare oxidative stress markers in hyperthyroid, hypothyroid, and euthyroid individuals.
  • To investigate the levels of enzymatic antioxidants (ARS), endogenous peroxides (POX), non-enzymatic antioxidants (Antiox-cap), and anti-oxidized low-density lipoprotein (LDL) antibody titers (oLAb).

Main Methods:

  • Plasma samples were collected from 34 hyperthyroid patients (TSH <0.04), 34 hypothyroid patients (TSH >4.0), and 34 healthy euthyroid controls.
  • Levels of POX, ARS, Antiox-cap, and oLAb were measured in all participants.

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Main Results:

  • Endogenous peroxides (POX) were highest in hyperthyroid patients.
  • Enzymatic antioxidants (ARS) were significantly elevated in both hyperthyroid and hypothyroid patients compared to controls.
  • Non-enzymatic antioxidants (Antiox-cap) were significantly lower in patients.
  • Anti-oxidized LDL antibody titers (oLAb) were significantly higher in hypothyroid patients.

Conclusions:

  • Both hyperthyroidism and hypothyroidism are associated with increased oxidative stress.
  • Elevated POX in hyperthyroidism may be linked to the hypermetabolic state.
  • Higher oLAb in hypothyroidism suggests an increased risk of atherosclerosis progression.