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Lymph node infarction. An immunohistochemical study of 11 cases
James A Strauchen1, Lorraine K Miller
1Department of Pathology, Mount Sinai School of Medicine, New York, NY 10029, USA. james.strauchen@msnyuhealth.org
Archives of Pathology & Laboratory Medicine
|January 11, 2003
Summary
Lymphoid antigens are often preserved in infarcted lymph nodes, making immunohistochemistry a useful tool for diagnosing lymphoma. This technique can aid in evaluating lymph node infarction when traditional histology is insufficient.
Area of Science:
- Pathology
- Immunohistochemistry
- Oncology
Background:
- Lymph node infarction diagnosis can be challenging with histology alone.
- The utility of immunohistochemistry in evaluating lymph node infarction is not well-established.
- Necrotic tissue is often considered unsuitable for immunohistochemical analysis.
Observation:
- This study investigated lymphoid antigen preservation in infarcted lymph nodes.
- Immunohistochemical staining was retrospectively performed on archival tissues.
- The study included eleven adult patients with lymph node infarction.
Findings:
- Lymphoid antigens were preserved in 4 of 6 cases of lymph node infarction associated with lymphoma.
- Specific lymphoma subtypes identified included diffuse large B-cell lymphoma and peripheral T-cell lymphoma.
- No nonspecific staining was observed, and one case with benign antigen expression showed no lymphoma development over 5 years.
Implications:
- Immunohistochemistry is a valuable tool for evaluating lymph node infarction.
- Preserved lymphoid antigens in infarcted lymph nodes can aid in lymphoma diagnosis.
- This approach may improve diagnostic accuracy in challenging cases.