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Erythrocyte surface membrane alterations.

H B Bosmann, D M Gersten, R C Griggs

    Archives of Neurology
    |February 1, 1976
    PubMed
    Summary
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    Electrophoretic mobility studies reveal altered red blood cell surface properties in muscular dystrophy. These findings suggest muscular dystrophy may be a systemic membrane disease affecting more than just muscle tissue.

    Area of Science:

    • Biochemistry
    • Cell Biology
    • Genetics

    Background:

    • Muscular dystrophy is a group of inherited disorders characterized by progressive muscle weakness and degeneration.
    • While primarily affecting skeletal muscle, emerging evidence suggests potential systemic involvement.

    Purpose of the Study:

    • To investigate erythrocyte (red blood cell) surface electrokinetic properties in various models of muscular dystrophy.
    • To determine if observed alterations support a systemic membrane defect in muscular dystrophy.

    Main Methods:

    • Electrophoretic mobility measurements were performed on red blood cells.
    • Samples were obtained from patients with Duchenne and myotonic muscular dystrophy, as well as from dystrophic mice and chickens and their respective controls.

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    Main Results:

    • Significant alterations in erythrocyte surface electrokinetic properties were observed in dystrophic mice and chickens.
    • Many, but not all, patients with muscular dystrophy exhibited similar changes in red blood cell properties.

    Conclusions:

    • The findings indicate that muscular dystrophy is associated with systemic changes in cell membrane electrokinetic properties.
    • These results support the hypothesis of muscular dystrophy as a systemic membrane disease, extending beyond muscle tissue.