Aphakic bullous keratopathy treated with prosthokeratoplasty. An analysis of 34 consecutive cases

Area of Science:

• Ophthalmology
• Biomaterials Science
• Surgical Innovation

Background:

• Aphakic bullous keratopathy presents a significant challenge in corneal disease management.
• Advanced cases often require complex surgical interventions beyond standard penetrating keratoplasty.
• The Cardona keratoprosthesis offers an alternative prosthetic option for severe corneal opacity.

Purpose of the Study:

• To evaluate the efficacy and safety of the Cardona keratoprosthesis as a primary treatment for advanced aphakic bullous keratopathy.
• To compare the outcomes and complications of the Cardona keratoprosthesis with those of traditional penetrating keratoplasty.

Main Methods:

• A cohort of 34 eyes with advanced aphakic bullous keratopathy underwent primary implantation of the Cardona keratoprosthesis.
• Patient outcomes were monitored over follow-up periods ranging from 6 to 72 months.
• Complications such as extrusion and infection were recorded and analyzed.

Main Results:

• A notable improvement in visual function was observed in 28 out of 34 eyes (82%).
• Complications included three device extrusions (9%), with two cases linked to infection.
• Two eyes (6%) experienced worsened conditions due to vitreous hemorrhage or potential infection.

Conclusions:

• The Cardona keratoprosthesis demonstrates significant potential for improving vision in eyes with advanced aphakic bullous keratopathy.
• While effective, potential complications like extrusion and infection necessitate careful patient selection and monitoring.
• This prosthetic approach offers a viable alternative to penetrating keratoplasty for specific patient profiles.