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Updated: Aug 9, 2026
06:46
A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
Published on: July 5, 2022
Screening based on risk factors for gestational diabetes in an Asian population
P T Wagaarachchi1, L Fernando, P Premachadra
1Castle Street Hospital for Women, Colombo, Universities of Kelaniya and Sri Jayawardhanepura, Sri Lanka.
Summary
Universal screening for gestational diabetes mellitus (GDM) is recommended, as common risk factors like age and BMI miss over 40% of cases. Early detection through widespread testing is crucial for maternal and infant health.
Area of Science:
- Obstetrics and Gynecology
- Endocrinology
- Public Health
Background:
- Gestational diabetes mellitus (GDM) affects maternal and infant health.
- Identifying risk factors for GDM is essential for timely diagnosis and management.
- Current risk-based screening strategies may not be sufficiently sensitive.
Purpose of the Study:
- To evaluate the effectiveness of traditional risk factors in predicting gestational diabetes mellitus (GDM).
- To determine the prevalence of GDM in a cohort of 1004 women undergoing oral glucose tolerance testing (OGTT).
- To assess the implications of risk factor-based screening versus universal screening for GDM detection.
Main Methods:
- Retrospective analysis of oral glucose tolerance testing (OGTT) results from 1004 consecutive women.
- Examination of established GDM risk factors: maternal age, body mass index (BMI), family history of diabetes, history of macrosomic babies, unexplained perinatal loss, and parity.
- Comparison of GDM prevalence based on the presence or absence of individual and combined risk factors.
Main Results:
- GDM was diagnosed in 4.08% of the studied population.
- Increased risk of GDM was observed in women over 35 years (7.8%), with BMI ≥30 (8.1%), and a family history of diabetes (5.2%).
- Risk factors alone predicted only 58.5% of GDM cases, indicating a significant miss rate (>40%) with selective screening.
Conclusions:
- Selective screening for GDM based on conventional risk factors is insufficient and misses a substantial proportion of cases.
- Universal screening for GDM is supported by these findings to ensure comprehensive detection.
- Implementing universal screening can improve early diagnosis and management of GDM, benefiting maternal and fetal outcomes.
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