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Related Experiment Videos

Disseminated blastomycosis.

Ragheb A Assaly1, Jeffrey R Hammersley, Dan E Olson

  • 1Department of Medicine, Division of Pulmonary/Critical Care, Medical College of Ohio, Ruppert Health Center, Toledo 43614-5809, USA.

Journal of the American Academy of Dermatology
|January 11, 2003
PubMed
Summary
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A Saudi Arabian woman had Blastomyces dermatitidis causing lung and skin lesions. Treatment with itraconazole led to significant improvement in her Blastomycosis symptoms within six weeks.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Pulmonology

Background:

  • Blastomycosis is a fungal infection caused by Blastomyces dermatitidis, typically affecting the lungs and skin.
  • While endemic in North America, rare cases are reported globally, posing diagnostic challenges.

Observation:

  • A 26-year-old Saudi Arabian woman presented with hemoptysis and disseminated skin and lung nodules/abscesses.
  • Microscopic examination of skin biopsy revealed yeast forms, and fungal cultures from skin and bronchoscopy confirmed Blastomyces dermatitidis.

Findings:

  • The patient was treated with oral itraconazole 200 mg twice daily.
  • Significant improvement in both pulmonary and cutaneous lesions was observed within 6 weeks of initiating antifungal therapy.

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Implications:

  • This case highlights the importance of considering Blastomycosis in patients with disseminated fungal infections, even outside endemic areas.
  • Successful treatment with itraconazole demonstrates its efficacy in managing pulmonary and cutaneous Blastomycosis.