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Abstract:
The sera pool of the human blood containing TTV DNA were administered to mice intravenously and then every 10 days examinations were made of blood serum and different organs of inoculated mice by polymerase chain reaction for presence of the viral nucleotide sequences. The viral DNA was revealed in the blood serum, the liver, kidneys and other organs 20 days after infection and persisted in most of the animals during 80 days. The data obtained show the possibility of TTV-infection of mice.
Insights
Mice can be infected with Torque teno virus (TTV). Viral DNA was detected in mouse blood and organs up to 80 days post-infection, demonstrating TTV
Area of Science:
- Virology
- Infectious Diseases
Context:
- Human blood sera containing Torque teno virus (TTV) DNA were used.
- Intravenous administration was employed for inoculation.
Purpose:
- To investigate the susceptibility of mice to TTV infection.
- To determine the dissemination and persistence of TTV in mice.
Summary:
- Viral DNA was detected in mouse blood serum, liver, and kidneys.
- TTV DNA was identified 20 days post-infection and persisted for up to 80 days in most animals.
- Polymerase chain reaction (PCR) was used to detect viral nucleotide sequences.
Impact:
- Establishes a potential animal model for studying TTV infection.
- Provides evidence for the possibility of TTV infection in mice.
- Suggests further research into TTV pathogenesis and transmission in mammalian models.