Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Visual hallucinations associated with zonisamide.

Cigdem I Akman1, Howard P Goodkin, Donald P Rogers

  • 1Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Pharmacotherapy
|January 14, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

New-onset refractory status epilepticus/febrile infection-related epilepsy syndrome centers of excellence: A framework for coordinated care, research, and improved outcomes.

Epilepsia·2026
Same author

Reducing Time to Seizure Treatment in a Pediatric Intensive Care Unit Through Quality Improvement Methodology: Seizure to Rescue.

Neurology. Clinical practice·2026
Same author

A small but welcome light on the child-adult transition in epilepsy.

Archives of disease in childhood·2026
Same author

Goosebumps and chills: bilateral piloerection as a manifestation of right mesial temporal epilepsy.

Epilepsy & behavior reports·2026
Same author

Trends in antiseizure medication monotherapy for pediatric epilepsy in the United States.

Epilepsia open·2026
Same author

Responsive neurostimulation in children, adolescents, and young Adults-Longitudinal effectiveness and safety.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics·2026
Same journal

The Effect of Multiple Doses of Itraconazole on the Pharmacokinetics of a Single Oral Dose of Zongertinib in Healthy Male Volunteers.

Pharmacotherapy·2026
Same journal

Menopausal Hormone Therapy: A Narrative Review of Contemporary Evidence.

Pharmacotherapy·2026
Same journal

Getting It Right the Second Time: How Can we Optimize First-Generation Cephalosporin Dosing for Skin and Soft Tissue Infections in the 21st Century?

Pharmacotherapy·2026
Same journal

Buprenorphine Initiation During Extracorporeal Membrane Oxygenation Decreases Sedative and Opioid Exposure: A Retrospective Matched Case-Control Study.

Pharmacotherapy·2026
Same journal

Voriconazole Dosing and Therapeutic Drug Monitoring in Patients Before and After Liver Transplantation.

Pharmacotherapy·2026
Same journal

Quantifying the Serum Magnesium Response and Predictors of Response Following Intravenous Magnesium Replacement in Critically Ill Patients.

Pharmacotherapy·2026
See all related articles

Zonisamide, an antiepileptic drug, may cause visual hallucinations and altered mental status in some epilepsy patients. Symptoms resolved upon zonisamide dosage reduction or discontinuation.

Area of Science:

  • Neuroscience
  • Pharmacology

Background:

  • Zonisamide is a broad-spectrum antiepileptic drug.
  • It is prescribed for various seizure types.

Observation:

  • Three epilepsy patients developed complex visual hallucinations and altered mental status.
  • These events occurred after initiating or increasing zonisamide dosage.
  • Hallucinations did not correlate with EEG findings or video monitoring.

Findings:

  • Zonisamide treatment was associated with new-onset visual hallucinations.
  • Symptoms resolved with zonisamide dose reduction or discontinuation.
  • No prior history of visual hallucinations was reported in these patients.

Implications:

  • Clinicians should consider zonisamide as a potential cause of visual hallucinations.

Related Experiment Videos

  • Further research is needed to clarify this potential adverse effect.
  • Awareness of this complication is crucial for patient safety.