Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dydrogesterone and endometriosis.

W I Johnston

    British Journal of Obstetrics and Gynaecology
    |January 1, 1976
    PubMed
    Summary

    Dydrogesterone effectively treated endometriosis symptoms in 49 patients, with most becoming symptom-free within nine months. This hormonal therapy also improved fertility, with 10 of 19 patients achieving pregnancy.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Necrospermia and chronic spinal cord injury.

    Fertility and sterility·2000
    Same author

    Artificial insemination and in-vitro fertilization using donor spermatozoa: a report on 15 years of experience.

    Human reproduction (Oxford, England)·1997
    Same author

    Intracytoplasmic sperm injection and embryo development of human oocytes cryopreserved using 1,2-propanediol.

    Human reproduction (Oxford, England)·1995
    Same author

    Intracytoplasmic sperm injection: a major advance in the management of severe male subfertility.

    Fertility and sterility·1995
    Same author

    Parthenogenetic activation of human oocytes following cryopreservation using 1,2-propanediol.

    Human reproduction (Oxford, England)·1995
    Same author

    The use of intracytoplasmic sperm injection for the treatment of severe and extreme male infertility.

    Reproduction, fertility, and development·1995

    Area of Science:

    • Reproductive Medicine
    • Endocrinology
    • Gynecology

    Background:

    • Endometriosis is a chronic, estrogen-dependent inflammatory disease.
    • Current treatments for endometriosis have limitations and side effects.
    • Effective and safe therapeutic options are needed for endometriosis management.

    Purpose of the Study:

    • To evaluate the efficacy and safety of dydrogesterone in treating endometriosis.
    • To assess the impact of dydrogesterone on endometriosis-related symptoms and patient fertility.

    Main Methods:

    • A study involving 49 patients diagnosed with endometriosis.
    • Administration of dydrogesterone at a dosage of 5 mg twice daily for nine months.
    • Assessment of symptom resolution, including dyspareunia, via patient reporting and follow-up culdoscopies.

    Main Results:

    • 44 out of 49 patients (89.8%) achieved symptom freedom after nine months of dydrogesterone therapy.
    • Significant reduction in subjective endometriosis symptoms within 4-8 weeks, with dyspareunia resolution taking longer.
    • Culdoscopic confirmation of endometriosis 'cure' in 30 of 32 patients.
    • Increased pregnancy rates in infertile patients, with 10 out of 19 achieving pregnancy.
    • Dydrogesterone was well-tolerated, with only transient mastalgia and dizziness reported in two patients.

    Conclusions:

    • Dydrogesterone is a highly effective treatment for endometriosis, leading to significant symptom relief and objective improvements.
    • The hormonal therapy demonstrates a favorable safety profile with minimal side effects.
    • Dydrogesterone offers a promising therapeutic option for improving fertility outcomes in women with endometriosis.

    Related Experiment Videos