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Changes in lymphocyte function during pregnancy.

O M Petrucco, R F Seamark, K Holmes

    British Journal of Obstetrics and Gynaecology
    |March 1, 1976
    PubMed
    Summary
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    Pregnancy increases spontaneous lymphocyte DNA synthesis, but reduces PHA-induced transformation. Pre-eclampsia, especially severe forms, alters these immune responses, suggesting complex immune system adaptations during gestation.

    Area of Science:

    • Immunology
    • Reproductive Biology
    • Cell Biology

    Background:

    • Pregnancy involves significant immune system modulation.
    • Lymphocyte function is crucial for immune responses.
    • Changes in lymphocyte activity during pregnancy and pre-eclampsia require further investigation.

    Purpose of the Study:

    • To investigate changes in lymphocyte DNA synthesis and phytohemagglutinin (PHA)-induced transformation during pregnancy.
    • To examine the impact of pre-eclampsia on these lymphocyte functions.
    • To explore the role of specific hormones in modulating lymphocyte activity.

    Main Methods:

    • Autoradiography to assess lymphocyte DNA synthesis.
    • Culture of lymphocytes with PHA in fetal calf serum and autologous serum.

    Related Experiment Videos

  • In vitro experiments with hormones like cortisol, progesterone, and human placental lactogen (HPL).

    • Main Results:

    • Spontaneous lymphocyte DNA synthesis increased gradually throughout pregnancy.
    • PHA-induced lymphocyte transformation decreased significantly in the second and third trimesters.
    • Mild pre-eclampsia reduced spontaneous lymphocyte DNA synthesis, while severe pre-eclampsia showed no significant difference compared to controls.
    • Cortisol and progesterone significantly inhibited lymphocyte DNA synthesis in vitro, with progesterone showing a dose-dependent effect.

    Conclusions:

    • Lymphocyte DNA synthesis and PHA-induced transformation are altered during normal pregnancy.
    • Pre-eclampsia affects these immune parameters, particularly in milder forms.
    • Hormonal factors, notably cortisol and progesterone, play a role in suppressing lymphocyte activity during pregnancy.