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Mouse models as tools for dissecting disorders of lipoprotein metabolism
Peter Marschang1, Joachim Herz
1Department of Molecular Genetics, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, 75390-9046, USA.
Seminars in Cell & Developmental Biology
|January 14, 2003
Abstract:
The overexpression of proteins as transgenes or by adenovirus-mediated gene transfer as well as the disruption of genes by homologous DNA recombination in the mouse provide powerful tools to dissect the role of individual proteins in complex biological pathways. These and similar techniques have been widely used to characterize the function of most of the players involved in lipoprotein metabolism. These models are expected to greatly advance the finding of new therapeutic strategies for the treatment of disorders of lipoprotein metabolism.