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Rat nerve regeneration through a silicone chamber implanted with negative carbon ions
Ryosuke Ikeguchi1, Ryosuke Kakinoki, Taiichi Matsumoto
1Department of Orthopedic Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan.
Brain Research. Developmental Brain Research
|January 14, 2003
Abstract:
We investigated whether a tube with its inner surface implanted with negatively-charged carbon ions (C(-) ions) would enable axons to extend over a distance greater than 10 mm. The tube was found to support nerves regenerating across a 15-mm-long inter-stump gap. Silicone treated with C(-) ions showed increased hydrophilic properties and cellular affinity, and axon regeneration was promoted with this increased biocompatibility.