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Nanoparticle-mediated gene delivery to tumour neovasculature
Andrew R Reynolds1, S Moein Moghimi, Kairbaan Hodivala-Dilke
1Cell Adhesion and Disease Laboratory, Cancer Research UK, Richard Dimbleby Department of Cancer Research, St. Thomas' Hospital, Lambeth Palace Road, London SE1 7EH, UK.
Trends in Molecular Medicine
|January 14, 2003
Abstract:
The alpha(v)beta(3) integrin is a potential pharmacological target for anti-angiogenic therapy. A recent report describes the use of alpha(v)beta(3)-targeted nanoparticles to deliver a gene to tumour vasculature selectively. This resulted in substantial tumour regression in several experimental mouse tumour models. Hence, this approach has great potential for the treatment of human cancer.