Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The dynamics of thrombin formation.

Kenneth G Mann1, Saulius Butenas, Kathleen Brummel

  • 1Department of Biochemistry, University of Vermont, College of Medicine, Burlington, Vt 05405, USA. kmann@zoo.uvm.edu

Arteriosclerosis, Thrombosis, and Vascular Biology
|January 14, 2003
PubMed
Summary

Thrombin generation via the tissue factor pathway is crucial for hemostasis but can cause dangerous clots when dysregulated. This review details thrombin generation, its regulation, and implications for vascular diseases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prothrombotic fibrin clot phenotype in obstetric antiphospholipid syndrome: clinical implications and unanswered questions. Authors' reply.

Polish archives of internal medicine·2026
Same author

Altered fibrin clot properties and the risk of thromboembolism in women with obstetric antiphospholipid syndrome: a cohort study.

Polish archives of internal medicine·2025
Same author

Beyond prothrombin time and activated partial thromboplastin time: coagulation in vivo-an illustrated review.

Laboratory medicine·2025
Same author

Elevated carbonylated proteins are associated with major cardiovascular events in patients with chronic coronary syndrome: A cohort study.

Kardiologia polska·2024
Same author

Elevated factor XIa as a modulator of plasma fibrin clot properties in coronary artery disease.

European journal of clinical investigation·2023
Same author

Anti-FVIII antibodies in Black and White hemophilia A subjects: do F8 haplotypes play a role?

Blood advances·2022

Area of Science:

  • Biochemistry
  • Hematology
  • Physiology

Background:

  • Hemostasis relies on thrombin generation, primarily through the tissue factor pathway.
  • Thrombin plays complex roles in regulating its own production and degradation.
  • Dysregulated thrombin generation is implicated in major vascular occlusive events.

Purpose of the Study:

  • To review current understanding of the tissue factor pathway in thrombin generation.
  • To elucidate the roles of extrinsic and intrinsic factor Xa generating complexes in hemostasis.
  • To summarize the function of regulatory inhibitors in controlling thrombin generation.

Main Methods:

  • Literature review of the tissue factor pathway and hemostasis.
  • Analysis of the roles of factor Xa generating complexes.

Related Experiment Videos

  • Examination of stoichiometric and dynamic thrombin inhibitors.

    • Main Results:

    • Detailed overview of the tissue factor pathway's central role in initiating coagulation.
    • Explanation of how extrinsic and intrinsic pathways contribute to factor Xa generation.
    • Summary of the inhibitory mechanisms governing thrombin production.

    Conclusions:

    • The tissue factor pathway is a tightly regulated system essential for hemostasis.
    • Imbalances in thrombin generation contribute to thrombotic disorders, particularly in aging populations.
    • Understanding these pathways and their regulation is key to managing hemostatic and thrombotic diseases.