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NF-kappaB activation by protein kinase C isoforms and B-cell function

Jorge Moscat1, María T Diaz-Meco, Paul Rennert

  • 1Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas-Universidad Autonoma de Madrid, Canto Blanco, Spain. jmoscat@cbm.uam.es

EMBO Reports
|January 14, 2003
PubMed

B cells are essential to the immune response in health and disease. Results from knockout (KO) mice for different members of the nuclear factor-kappaB (NF-kappaB) family have highlighted the importance of this transcription factor in B cell development and function. The recent generation of additional KO mice for adapters and kinases implicated in NF-kappaB activation, including several protein kinase C isoforms, has provided new insights into the roles of these proteins in B cell signalling. These studies have also given rise to a number of important questions that must be answered with further experimentation to establish accurately the signalling pathways that regulate B-cell function through NF-kappaB.

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